Hypoplastic Left Heart

Hypop bearic 1 Running Head: HYPOPLASTIC LEFT HEART SYNDROME Hypoplastic unexp dyinged breast Syndrome Hypoplastic 2 Hypoplastic remaining(p) heart syndrome (HLHS) is congenital abnormality in which the left grimace of the heart is severely underdeveloped. It is often associated with mitral atresia, aortal atresia, or both(prenominal) (http://www.accessmedicine.com, 2008). When the left-side heart structures are underdeveloped, the shine side of the heart must pump blood to both the lungs and to the quiet of the body. In HLHS, pulmonary venous blood enters the left atrium notwithstanding systole is unable to push the blood across the constricted or absent mitral valve into the left ventricle. The blood quite is shunted into the right atrium through the PDA, where it contributes to volume loading of the right ventricle. The end military issue is pulmonary venous hypertension, right ventricul ar failure, and profound underperfusion of coronary thrombosis arteries and vital organs (http://www.accessmedicine.com, 2008). Despite rummy advances in the diagnosis and treatment of HLHS, it remains one of the well-nigh therapeutically gainsay and least-understood forms of congenital heart disease. HLHS is a obsolescent defect, occurring in 0.016%-0.

036% of function births (Bove, 2002). However, it continues to be the leading cause of sister death callable to cardiovascular malformation (CVM) and is associated with significant long morbidity (JACC, 2007). During the last 50 years th ere has been increase evidence that supports! a genetic etiology for HLHS. In the diary of the American College of Cardiology, Hinton et al performed a study to determine the surface of heritability in families set by a HLHS proband. They found that HLHS was almost exclusively the resolution of a genetic cause. Fifty-five per centum of the families had 1 or more affected family members and rate among siblings was 8%. cardinal percent of the siblings also had an additional CVM....If you want to get a blanket(a) essay, order it on our website: BestEssayCheap.com

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